Jump to main content
Jump to site search
SCHEDULED MAINTENANCE Close the message box

Maintenance work is planned for Monday 16 August 2021 from 07:00 to 23:59 (BST).

Website performance may be temporarily affected and you may not be able to access some PDFs or images. If this does happen, refreshing your web browser should resolve the issue. We apologise for any inconvenience this might cause and thank you for your patience.

All chapters


The Prokaryotic Mo/W-bisPGD Enzymes Family

Over the past two decades, prominent importance of molybdenum/tungsten-containing enzymes in prokaryotes has been put forward by studies originating from different fields providing a unique combination of knowledge. Proteomic or bioinformatic studies underpinned that the list of molybdenum/tungsten-containing enzymes is far from being complete with, to date, more than 50 different enzymes involved in the biogeochemical nitrogen, carbon and sulfur cycles. In particular, the vast majority of prokaryotic molybdenum-/tungsten-containing enzymes belong to the so-called DMSO reductase family. Despite its extraordinary diversity, this family is characterized by the presence of a Mo/W-bis(pyranopterin guanosine dinucleotide) cofactor at the active site with a yet uncovered reactivity. This chapter highlights the substrate specificity of their catalytic site, the modular variation of their structural organization and their contribution to the bioenergetics of prokaryotes.

Publication details

Print publication date
28 Sep 2016
Copyright year
Print ISBN
ePub eISBN
From the book series: