Abundance, Ubiquity and Evolution of Molybdoenzymes
This chapter summarizes bioinformatics studies of molybdenum-containing enzymes given the dramatic increase in the production of genomic sequences that are now available for a large number of organisms from all three domains of life. These data provide an opportunity to examine occurrence and evolutionary patterns of genes, pathways and biological processes, including molybdenum utilization and molybdoenzymes. Comprehensive analyses have greatly facilitated our understanding of how Mo is used by different organisms and how the distribution and biological functions of molybdoenzymes have been shaped by evolutionary processes. Here, we focus on recent developments involving comparative genomic analyses of Mo utilization and discuss the occurrence and abundance of molybdoenzymes as well as the macroevolutionary trends of molybdenum utilization.