All chapters

CHAPTER 8

Chelators for Diagnostic Molecular Imaging with Radioisotopes of Copper, Gallium and Zirconium

The radiometallic isotopes 64Cu, 68Ga and 89Zr have immense utility in molecular PET imaging. The ability to prepare clinically useful 64Cu, 68Ga and 89Zr radiopharmaceuticals is contingent on efficient chelators that enable access to simple radiolabelling methodologies, as well as providing metal complexes that are highly stable in vivo. This review highlights how the different design requirements for 64Cu2+, 68Ga3+ and 89Zr4+ chelators are dictated by not only each specific metal ion’s coordination preferences, but also the radionuclide’s half-life, the biomolecular vehicle to which the complex is attached, and the molecular process being targeted.

Publication details

Print publication date
26 Oct 2016
Copyright year
2017
Print ISBN
978-1-78262-064-8
PDF eISBN
978-1-78262-389-2
ePub eISBN
978-1-78262-921-4

From the book series:
Metallobiology