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Application of NMR in drug discovery

The use of solution Nuclear magnetic resonance (NMR) techniques (NMR) in the field of drug discovery and drug design has become indispensable in both academia and industry. This review covers the several advances and trends of NMR in the field. The applications are roughly clasified into the two categories of techniques, “protein-based” and “ligand-based”, both of which are oriented to fragment-based drug discovery (FBDD) approaches. Marked number of the efforts are made to develop novel assignment methods for intrinsically disordered proteins (IDP), that is a potential drug target. Other trends include in-cell NMR and NMR metabolomics.

Publication details

Print publication date
28 Apr 2016
Copyright year
2016
Print ISBN
978-1-78262-053-2
PDF eISBN
978-1-78262-410-3
ePub eISBN
978-1-78262-869-9