Risk Factors for Hypertension and Cardiovascular Disease
Chapter 8 reviews the disease burden of traditional risk factors (hypertension, dyslipidemia, obesity, diabetes, diet, and smoking), as well as emerging risks (pollution, sleep apnea, chronic obstructive pulmonary disease and psychosocial stress). In each instance, vascular injury is associated with inflammation and oxidative stress. The role of autonomic imbalance in this process is also considered. An understanding of the pathophysiology of the vascular injury may suggest new targets for drug therapy for cardiovascular disease prevention.