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Chapter 4

(Benz)imidazoles

Imidazoles and benzimidazoles are quite unique and universal scaffolds, which are core units in numerous drugs and drug candidates. Exhibiting unique properties, they can be viewed as amide-bond and indole bioisosters, but offering additional options for interactions. After a more general description of their intrinsic physicochemical and structural properties, the most important, as well as instructive examples of marketed drugs utilizing imidazoles and benzimidazoles as scaffolds will be presented and briefly discussed.

Print publication date: 20 Nov 2015
Copyright year: 2016
Print ISBN: 978-1-78262-030-3
PDF eISBN: 978-1-78262-224-6
ePub eISBN: 978-1-78262-779-1
From the book series:
Drug Discovery