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CHAPTER 7

Disrupted-in-Schizophrenia-1 (DISC1) Interactome and Schizophrenia

Disrupted-in-schizophrenia-1 (DISC1) has captured much attention, because it predisposes individuals to such a psychiatric disorder as schizophrenia. Notably, a number of genes encoding proteins that interact with DISC1 are also considered to be relevant risk factors for this mental disorder. Accumulating studies reveal a role of DISC1 and its interacting proteins in early neurodevelopment and the regulation of synaptic functioning. We reason that the understanding of schizophrenia in the context of the DISC1 interactome will help to understand the neurobiological mechanisms of schizophrenia. Given that DISC1 is associated with a wide range of endophenotypes, systematic integration of the functional roles of each of the DISC1 interacting proteins would contribute to a better resolution of the neurobiological mechanisms of schizophrenia and ultimately lead to the development of preventive therapy.

Publication details


Print publication date
13 May 2015
Copyright year
2015
Print ISBN
978-1-78262-026-6
PDF eISBN
978-1-78262-249-9
ePub eISBN
978-1-78262-504-9
From the book series:
Drug Discovery