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Chapter 10

Strength in Flexibility: Modeling Side-Chain Conformational Change in Docking and Screening

Modeling protein flexibility in structure-based drug design and virtual screening remains a strong challenge due to the number of degrees of freedom involved and the co-optimization of protein and ligand shape and chemistry. However, there is a growing trend towards incorporating some protein side-c...

Publication details


Print publication date
26 Oct 2007
Copyright year
2007
Print ISBN
978-0-85404-365-1
PDF eISBN
978-1-84755-796-4
From the book series:
RSC Biomolecular Sciences