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Chapter 13

Receptor-Mediated Regulation of Cytochromes P450

In the early 1960s, barbiturates were found to induce enzymes in the liver endoplasmic reticulum and to increase their own metabolism.1 With this finding, the induction by drugs of drug metabolism was suggested to be the mechanism associated with drug tolerance. Subsequently, cytochrome P450 (CYP), ...

Publication details


Print publication date
27 Jun 2008
Copyright year
2008
Print ISBN
978-0-85404-274-6
PDF eISBN
978-1-84755-842-8
From the book series:
Issues in Toxicology