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Chapter 5

The Hairpin and Varkud Satellite Ribozymes

Nucleolytic ribozymes carry out cleavage at a specific site by transesterification reactions in which the 2′-oxygen attacks the 3′-phosphorus, with departure of the 5′-oxygen to leave a cyclic 2′-3′-phosphate. The reaction follows an SN2 mechanism, with inversion of configuration at the phosphorus. ...

Publication details


Print publication date
15 Nov 2007
Copyright year
2007
Print ISBN
978-0-85404-253-1
PDF eISBN
978-1-84755-798-8
From the book series:
RSC Biomolecular Sciences