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Chapter 15

Fluorination Approaches

The incorporation of fluorine containing fragments into organic molecules plays a pivotal role in medicinal chemistry today. Over the past 20 years, this field has undergone a paradigm shift, with the focus now moving to easily handled fluorinating reagents which are capable of introducing these desired structural motifs into sensitive drug-like scaffolds in a regioselective manner. This chapter will provide an overview of synthetic methods for the introduction of F, CF2H and CF3 groups into organic molecules with a focus on those of prime utility to practicing medicinal chemists.

Print publication date: 01 Aug 2016
Copyright year: 2016
Print ISBN: 978-1-78262-786-9
PDF eISBN: 978-1-78262-791-3
ePub eISBN: 978-1-78262-792-0
From the book series:
Drug Discovery