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Chapter 12

AI via Matched Molecular Pair Analysis

Matched molecular pair analysis (MMPA) is a well accepted, transparent SAR analysis method that also enables the generation of new molecules to address a biological or physicochemical goal. This makes it an ideal component of a compound discovery artificial intelligence platform. The methods and challenges of supervised and unsupervised MMPA are addressed with the additional issues of conducting analysis on a large scale and automating processes. Extensions of MMPA to apply to potency data via either matched molecular series or exploiting protein structural data are also reviewed. The opportunities for further developments in the field are discussed.

Publication details


Print publication date
12 Nov 2020
Copyright year
2021
Print ISBN
978-1-78801-547-9
PDF eISBN
978-1-78801-684-1
ePub eISBN
978-1-83916-054-7
From the book series:
Drug Discovery