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Chapter 6

Enzyme-Responsive Hydrogels for Biomedical Applications

This chapter highlights recent developments in enzyme-responsive gels. The focus is on peptide-based small-molecule hydrogels, for biomedical applications. The use of enzymes in this context provides a powerful methodology for controlled assembly, taking advantage of both biological selectivity and catalytic amplification. The building blocks for self-assembly and basic design rules for small molecule peptide gelators are discussed first. This is followed by a discussion of key features of biocatalytic self-assembly of hydrogels, focusing on control of nanoscale organization and consequent function. Finally, the potential applications of the enzyme-responsive hydrogels as biomaterials are discussed in the areas of cell culture, drug delivery, biosensing, and control of cell fate.

Publication details


Print publication date
18 Mar 2014
Copyright year
2014
Print ISBN
978-1-84973-798-2
PDF eISBN
978-1-78262-205-5
ePub eISBN
978-1-78262-126-3
From the book series:
Soft Matter Series