Natural Polyphenol-Taurine based Nanoparticles for Oral Ulcer Therapy

Abstract

Oral ulcers are the most common self-limiting diseases of the oral mucosa and the pathogenes is caused by local overload of reactive oxygen species (ROS) that precipitates tissue breakdown, which in turn leads to the formation of ulcers. Here, we report one-step oxidative copolymerization strategy to synthesize pH/ROS dual-responsive protocatechualdehyde taurine nanoparticles (PAT NPs) by cross-linking protocatechualdehyde and taurine (Tau). These PAT NPs combine an excellent biocompatibility and multiple functions, such as efficient free radicals scavenging, neutralization of lipopolysaccharide, protection of mitochondria, inhibition of M1 macrophage polarization and promotion of M2 polarization, anti-inflammatory activity and promotion of cell migration and angiogenesis. The animal model of ulcer proved that they can simultaneously inhibit inflammation, promote vascularization, and significantly shorten the healing time of the ulcer, which provides a new paradigm for the translation of natural polyphenol-taurine nanomaterials in the field of oral mucosal repair.