Cu(II)-Catalyzed [3 + 2] Cycloaddition of Enaminones and N-Tosylaziridines Leading to 2,3-Dihydropyrroles
Abstract
A copper-catalyzed [3 + 2] cycloaddition reaction between N-tosylaziridines and enaminones has been developed for the synthesis of functionalized 2,3-dihydropyrroles under ambient conditions. This approach proceeds via a facile nucleophilic ring-opening step and tolerates a range of enaminones bearing diverse functional groups and substitution patterns
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