Cu(II)-Catalyzed [3 + 2] Cycloaddition of Enaminones and N-Tosylaziridines Leading to 2,3-Dihydropyrroles

Abstract

A copper-catalyzed [3 + 2] cycloaddition reaction between N-tosylaziridines and enaminones has been developed for the synthesis of functionalized 2,3-dihydropyrroles under ambient conditions. This approach proceeds via a facile nucleophilic ring-opening step and tolerates a range of enaminones bearing diverse functional groups and substitution patterns

Supplementary files

Article information

Article type
Research Article
Submitted
13 Mar 2026
Accepted
27 Apr 2026
First published
28 Apr 2026

Org. Chem. Front., 2026, Accepted Manuscript

Cu(II)-Catalyzed [3 + 2] Cycloaddition of Enaminones and N-Tosylaziridines Leading to 2,3-Dihydropyrroles

X. Zhang, S. Zhao, G. Lv, M. Chen, W. Li and X. Xu, Org. Chem. Front., 2026, Accepted Manuscript , DOI: 10.1039/D6QO00319B

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