An iridium-catalyzed intramolecular allylic substitution reaction: efficient enantioselective synthesis of 1,3,4-oxadiazine, oxazoline and 1,3-oxazine derivatives

Abstract

An efficient Ir-catalyzed enantioselective intramolecular allylic substitution reaction for the synthesis of five- and six-membered N,O-heterocyclic compounds has been achieved. This method offers a facile, straightforward access to a diverse range of 1,3,4-oxadiazines with good yields (up to 88%) and excellent enantioselectivities (up to 95% ee), while oxazolines and 1,3-oxazines have also been afforded with comparable yields and ee values.