Base-Promoted Synthesis of β-Keto Sulfone with N-Acyl Pyrroles and Allyl Sulfones

Abstract

An efficient method has been developed for the direct transformation of allyl sulfone to β-keto sulfones by their reaction with N-acyl pyrroles under transition metal-free conditions. Simply combining equivalent N-acyl pyrroles, allyl sulfones and NaN(SiMe3)2 enabled the preparation of a broad range of β-keto sulfones. Among the synthesis of such synthetically and biologically relevant structure, the route presented herein features photo and metal-free conditions, convenient operation, and excellent functional group compatibility 2 | J. Name., 2012, 00, 1-3This journal is