A transition-metal-free, radical-induced C-O cleavage of phenethyl ethers has been developed with a simple tBuONa/DMSO system under mild, non-photochemical, and non-electrochemical conditions. This method delivers styrenes and phenols with broad substrate scope and excellent functional-group tolerance, offering a conceptually novel approach for C-O bond fragmentation.
Z. Yan, Z. Zhang, F. Wang, L. Ye, S. Yue, X. Lei, J. Su, Z. Chen and H. Cai, Org. Biomol. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D6OB00427J
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