4-Chloro-2H-chromene-3-carbaldehyde: a valid scaffold in organic synthesis and future molecules for healthcare and energy

Abstract

In the past decade, 4-chloro-2H-chromene-3-carbaldehyde scaffolds (CCCS) have emerged as versatile precursors in modern organic synthesis. This review critically analyzes recent advancements in the chemical reactivity and synthetic accessibility of CCCS. We evaluate their pivotal role in developing potent agents against inflammation, cancer, and microbial resistance, while also addressing applications in energy sectors. By identifying the most efficient derivatives within each series, this work provides a strategic framework for leveraging CCCS in future pharmaceutical and materials science research.