BF3·Et2O-catalyzed dearomative spirocyclization of ynones for the synthesis of spirolactams and spirolactones

Abstract

This study presents a BF₃·Et₂O catalyzed intramolecular cyclization reaction of ynones, enabling the efficient synthesis of spiro-heterocyclic compounds, such as spiro-γ-lactams and spiro-γ-lactones. This reaction enables the synthesis of diverse spirocyclic compounds under metal-free and mild conditions, exhibiting broad substrate compatibility and excellent yields.