Three-component tandem benzyl-C(sp3)–H functionalization via thermally generated arynes with phenazine

Abstract

A rare strategy for three-component tandem benzyl-C(sp³)–H functionalization via thermally generated arynes with phenazine without a catalyst was developed for the first time. A series of novel fused N,N′-disubstituted dihydrophenazine derivatives were synthesized with excellent yield and high atomic utilization. Deuterium-labelling studies suggested that the formation of carboanion intermediates has a significant role in the reaction. Our data enrich the field of C(sp³)–H functionalization and promote the development of aryne chemistry.