Rhodium(II)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions

Haiqing Wang; Hekun Huang; Xinke Zhang; Chunan Wang; Zhuodi Chen; Chengyong Su; Xiang Fu; Wenhao Hu

doi:10.1039/D5OB01742D

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Rhodium(ii)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions

Haiqing Wang,^a Hekun Huang,

^a Xinke Zhang,^a Chunan Wang,^a Zhuodi Chen,^c Chengyong Su,

*^bc Xiang Fu

*^a and Wenhao Hu

*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
E-mail: fuxiang23@mail.sysu.edu.cn, huwh9@mail.sysu.edu.cn

^b Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, Sun Yat-Sen University, Guangzhou 510006, China

^c GBRCE for Functional Molecular Engineering, Lehn Institute of Functional Materials, IGCME, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China
E-mail: cesscy@mail.sysu.edu.cn

Abstract

We integrate a recyclable Rh-MOF heterogeneous catalyst into carbene-mediated three-component reactions of diazo compounds, alcohols and electrophiles. This system exhibits broad functional group tolerance, excellent diastereoselectivity, and high turnover number (TON = 856), while enabling continuous-flow gram-scale synthesis with prolonged operational stability.

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DOI: https://doi.org/10.1039/D5OB01742D
Article type: Communication
Submitted: 06 Nov 2025
Accepted: 03 Dec 2025
First published: 12 Dec 2025

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Org. Biomol. Chem., 2026, Advance Article

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Rhodium(II)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions

H. Wang, H. Huang, X. Zhang, C. Wang, Z. Chen, C. Su, X. Fu and W. Hu, Org. Biomol. Chem., 2026, Advance Article , DOI: 10.1039/D5OB01742D

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Organic & Biomolecular Chemistry

Rhodium(ii)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions

Abstract

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Rhodium(II)-incorporated metal–organic framework catalyst combined with flow chemistry for efficient carbene-mediated three-component reactions

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