Triazole Salicylaldehyde-Derived Organosilane as ‘Turn-On’ Fluorescence and Colorimetric Sensor for Ce(III): Synthesis, Anticancer and Molecular Docking Studies

Abstract

In the present investigation, a derivative salicylaldehyde triazole-functionalized silane (SS) was synthesized using a copper(I) -catalysed azide -alkyne cycloaddition (CuAAC) technique. The synthesized organosilane effective dual-mode chemosensor, enabling naked-eye colorimetric as well as a fluorescence-based detection of Ce(III). The detection limit (LOD) was found to be 0.51 x 10-7 M from absorption measurements and 0.32 x 10-7M from fluorescence studies. The 1:1 stoichiometric binding between SS and Ce(III) was further validated by Job’s plot. The mass ,FT-IR and 1H NMR spectrometry was used to clarify the coordination behaviour and binding site of the metal-ligand complex .The probe also exhibited promising anticancer activity, resulting in a 95.15% decrease in cell viability compared to control cells. Molecular docking analysis with 5HU9 further indicated strong binding interaction, with an energy of binding -9.06 kcal mol-¹.