Cu(II)/I2 Mediated Synthesis of α-Keto Esters via Csp2 -Csp Bond Cleavage of 1,2-Alkynediones Followed by C-O Bond Formation

Abstract

Herein, we disclose an efficient method for the synthesis of α-keto esters through a copper(II)/iodine-mediated reaction. The transformation involves the selective cleavage of the C(sp²)–C(sp) bond of 1,2-alkynediones, which is subsequently followed by C–O bond formation with alcohols. This protocol offers a broad substrate scope, accommodating a wide range of substrates to furnish the desired α-keto esters in good yields.