This work employs Lawesson's reagent under simple operational conditions and short reaction times to selectively introduce sulfur at C-2 in isatin, enabling access to a diverse range of 2-thioisatins. It fills a decades-long gap in isatin chemistry, allowing the synthesis of a new class of heterocycles and challenging the inherent reactivity of C-3.
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S. Cubas, H. Santos, M. T. Rodrigues Jr, L. A. Zeoly and F. Coelho, New J. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D5NJ04805B
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