A pyfluor mediated deoxyfluorination of 4-hydroxymethyloxazoles to 4-fluoromethyloxazoles under mild reaction conditions

Abstract

We report deoxyfluorination of 4-hydroxymethyloxazoles to 4-fluoromethyloxazoles in the presence of low-cost and thermally stable PyFluor with use of AgF under mild reaction conditions. Various substrates tolerated well and afforded the corresponding products in moderate to good yields.

Supplementary files

Article information

Article type
Communication
Accepted
03 Jan 2026
First published
08 Jan 2026

New J. Chem., 2026, Accepted Manuscript

A pyfluor mediated deoxyfluorination of 4-hydroxymethyloxazoles to 4-fluoromethyloxazoles under mild reaction conditions

K. M. Kajol, S. Kumar and R. Chintakunta, New J. Chem., 2026, Accepted Manuscript , DOI: 10.1039/D5NJ04715C

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