A pyfluor mediated deoxyfluorination of 4-hydroxymethyloxazoles to 4-fluoromethyloxazoles under mild reaction conditions
Abstract
We report deoxyfluorination of 4-hydroxymethyloxazoles to 4-fluoromethyloxazoles in the presence of low-cost and thermally stable PyFluor with use of AgF under mild reaction conditions. Various substrates tolerated well and afforded the corresponding products in moderate to good yields.
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