Effect of compound fish oil capsules on microvascular function in hypertensive individuals: a triple-blind, randomized, placebo-controlled pilot trial

Abstract

Background: Research indicates that Omega-3 fatty acids, resveratrol, astaxanthin, and coenzyme Q10 (CoQ10) possess anti-inflammatory properties, and the vascular benefits of them have been well-documented. The present study aimed to investigate the effects of compound fish oil capsules on cardiac, cutaneous, and cerebral microcirculation in hypertensive individuals.Methods: In a double-blind, randomized, placebo-controlled trial, 64 hypertensive patients were randomly assigned to either the compound fish oil (FO) group or the corn oil (CO) group (n = 32 per group) for a 3-week intervention. Participants were required to consume 2 capsules of the corresponding oil daily. The microcirculation functions of the heart, skin, and brain were examined by transthoracic Doppler echocardiography (TTDE), laser Doppler flowmeter (LDF), and magnetic resonance imaging (MRI), respectively. Data were primarily analyzed according to an intention-to-treat approach, supplemented with per-protocol analysis.