Advance and prospect of MIL-based drug delivery system in diagnosis and treatment of cervical cancer

Abstract

Cervical cancer, a common gynecological malignant tumor, poses a serious threat to women's health. Despite significant advances in cancer treatment, there is still a lack of effective early detection methods, and many therapeutic approaches suffer from low specificity and adverse side effects. Therefore, the urgent need is to explore efficient diagnostic methods and targeted treatments with strong specificity and high efficacy. The Materials of Institute Lavoisier (MIL) series are endowed with favorable porosity, large specific surface area, high drug-loading capacity and tunable pore size, along with superior chemical stability. Notably, their satisfactory biocompatibility further promotes their widespread research in cancer diagnosis and targeted therapy. Inspired by this, this review collects recent developments in the application of MIL materials in cervical cancer diagnosis and treatment. It primarily introduces the properties, structures, and synthesis methods of MIL materials, including MIL-100, MIL-101, MIL-88, and MIL-53. It then discusses the application of MIL materials in the diagnosis of cervical cancer. It reviews MIL-based nanoplatforms for chemotherapy (CT), chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), and related combination therapies in cervical cancer treatment. Finally, this review summarizes the challenges encountered in applying MIL materials to cervical cancer treatment and provides prospects for their future development.