PLATFORM UPDATE:
Selective recognition of i-motif DNA remains challenging due to its pH-dependent dynamics. Here, we report an i-motif templated target-guided synthesis that enables regioselective in situ formation of a 1,4-triazolyl carbazole (BPTC), which exhibits high affinity and selectivity for telomeric i-motif over G-quadruplex and duplex DNA, leading to potent telomerase inhibition.
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U. Saha, P. Paul, K. Fatma, R. Paul, S. Pradhan, Z. A. E. Waller and J. Dash, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC03102A
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