From the journal:

Chemical Communications

An Endoplasmic Reticulum-Directed ROS Burst Strategy Powered by H2O2 Abundance for Chemodynamic/Immuno Tumor Therapy

Ruixiang Liu,   Shurui Weng,   Jiayi Liu,   Yaru Cheng,   Conghui Liu  and  Tailin Xu  

Abstract

The endoplasmic reticulum (ER), enriched with H2O2, offers an ideal subcellular site to overcome the limited intracellular H2O2 supply in conventional chemodynamic therapy. By developing an ER-targeted chemodynamic nanoplatform, localized ROS bursts induce ER stress and immunogenic cell death, thereby amplifying antitumor immune activation and enabling a chemodynamic-immunotherapeutic strategy.

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Article information

DOI
https://doi.org/10.1039/D6CC02650H
Article type
Communication
Submitted
06 May 2026
Accepted
22 May 2026
First published
28 May 2026

Chem. Commun., 2026, Accepted Manuscript

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An Endoplasmic Reticulum-Directed ROS Burst Strategy Powered by H2O2 Abundance for Chemodynamic/Immuno Tumor Therapy

R. Liu, S. Weng, J. Liu, Y. Cheng, C. Liu and T. Xu, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC02650H

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