Nanozymes with controllable inhibition modes assist primary antithyroid drug screening

Abstract

The enzyme inhibition effect is vital in drug development. However, the high cost of enzymes becomes the main limitation. Hence, we report low-cost Pt_NP/NC nanozymes for screening antithyroid drugs via inhibition modes. As a concept application, a dual-channel sensor array accomplishes drug efficacy screening, laying a foundation for nanozyme-based inhibitor evaluation.