From the journal:

Chemical Communications

Unlocking a Modular Gd-DOTBA Platform via Tetramaleimide Click Chemistry for High-Performance MRI

Xinhui Xiao,   Shiyao Wang,   Peijie Guan,   Zhiqiang Wang  and  Lixiong Dai  

Abstract

A tetramaleimide-functionalized Gd-DOTBA scaffold (Gd-DOTBA-Mal) is developed as a modular platform for high-performance MRI probes. The maleimide groups enable site-specific bioconjugation. A cysteine conjugate exhibits high relaxivity and stability, enabling sensitive kidney dysfunction assessment and tumor imaging at half the clinical dose. This versatile platform facilitates advanced molecular MRI development.

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Article information

DOI
https://doi.org/10.1039/D6CC02219G
Article type
Communication
Submitted
16 Apr 2026
Accepted
20 May 2026
First published
21 May 2026

Chem. Commun., 2026, Accepted Manuscript

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Unlocking a Modular Gd-DOTBA Platform via Tetramaleimide Click Chemistry for High-Performance MRI

X. Xiao, S. Wang, P. Guan, Z. Wang and L. Dai, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC02219G

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