A self-assembled HDP-mimicking polypeptide micelle was developed for fungal keratitis treatment. The lead polylysine-b-polyleucine diblock polypeptide micelle showed potent activity against Fusarium solani, low cytotoxicity toward human corneal epithelial cells, and therapeutic efficacy comparable to voriconazole in vivo.
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H. Feng, X. Geng, H. Jia, X. Sun, M. Wang, D. Chu, Z. Guo, Z. Li and J. Li, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC02176J
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