From the journal:

Chemical Communications

Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Yu Zhang,   Honglei Zhu,   Qinqi Wang,   Leijiao Li,   Liana Shestakova,   Youry Ostrovsky,   Xincui Shi Shi,   Yuan Cui  and  Wenliang Li  

Abstract

Size-tunable hemoglobin-based oxygen carriers (Hb-Oxy) were synthesized via a template-assisted strategy and functionalized with caffeic acid (CA). The optimized Hb-CA building blocks exhibit an ideal P50 (35.84 mmHg) and >99% radical scavenging efficiency. Both micro-sized (L-Hb-CA) and nano-sized (S-Hb-CA) carriers constructed from these blocks retain excellent subunit cooperativity (Hill coefficient ~2.66), synergistically promoting wound healing (>97% closure in 10 days) by mitigating hypoxia and inflammation.

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Article information

DOI
https://doi.org/10.1039/D6CC02127A
Article type
Communication
Submitted
07 Apr 2026
Accepted
28 Apr 2026
First published
29 Apr 2026

Chem. Commun., 2026, Accepted Manuscript

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Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Y. Zhang, H. Zhu, Q. Wang, L. Li, L. Shestakova, Y. Ostrovsky, X. S. Shi, Y. Cui and W. Li, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC02127A

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