Diversified access to polysubstituted alkenes via photoredox-catalysed E1cb-type elimination reactions of allyl ethers with N-centered radical precursors

Abstract

Herein, a new photoredox-catalysed E1cb elimination protocol for the preparation of polysubstituted alkenes has been successfully developed. A range of N-centered radical precursors could react with allylic ethers, such as cycloketone oxime esters and α-imino-oxy acids. These reductive radical-polar crossover process-based procedures feature broad substrate scopes, good functional group tolerance, and general catalyst system.