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An ACy5-QL-BChE probe targeting butyrylcholinesterase (BChE) was developed using an anionic cyanine dye (ACy5-QL) with 762 nm emission. It achieved high signal-to-noise ratio in BChE detection for nonalcoholic fatty liver disease (NAFLD) across live cells, zebrafish, and mice by combining long-wavelength emission with enhanced ROS stability.
J. Li, Z. Zhang, S. Xu, H. Liu, W. Pan and M. Yan, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC01727D
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