No-wash immunosensors based on superhydrophilic covalent organic framework nanosheets with aggregation-induced emission for detecting carbohydrate antigen 19-9

Abstract

Enhancing the aggregation-induced emission (AIE) activity and hydrophilicity of AIE-covalent organic framework nanosheets (CONs) is important for improving the sensitivity of sandwich-type fluorescence-on immunosensors. This work developed 2,2′,2″,2‴-(ethene-1,1,2,2-tetrayltetrakis([1,1′-biphenyl]-4′,4-diyl))tetraacetonitrile-based AIE-CONs containing cyano and hydroxyl groups with high AIE activity and hydrophilicity to construct a highly sensitive immunosensor for detecting carbohydrate antigen 19-9.