Synthesis of Fluorinated 1,2-Naphthoquinones from o-Trifluoromethylbenzylamines via Defluorinative Approach

Abstract

A highly efficient and mild defluorinative methodology has been developed to synthesize various fluorinated 1,2-naphthoquinones from readily accessible o-trifluoromethylbenzylamine derivatives and enolizable esters. The resultant fluorinated 1,2-naphthoquinones are subsequently transformed into tetra-substituted indane and phenazine derivatives.

Supplementary files

Article information

Article type
Communication
Submitted
12 Mar 2026
Accepted
02 May 2026
First published
04 May 2026

Chem. Commun., 2026, Accepted Manuscript

Synthesis of Fluorinated 1,2-Naphthoquinones from o-Trifluoromethylbenzylamines via Defluorinative Approach

R. R. Kusmude, M. Yadav, S. A. Kale and S. Dhiman, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC01497F

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