An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition

Yuzheng Zhou; Die Hu; Xiang Li; Yang Xu; Peng He; Hong Zhou

doi:10.1039/D6CC01461E

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An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition

Yuzheng Zhou,^a Die Hu,^a Xiang Li,^a Yang Xu,^a Peng He*^a and Hong Zhou

*^a

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* Corresponding authors

^a Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Analytical Chemistry for Life Science and Intelligent Detection, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: zhouhong@qust.edu.cn

Abstract

We report an APE1/dual-miRNA-triggered ternary logic gate for high-fidelity tumor imaging. Sequential activation drives cascaded amplification, eliminating false positives and enabling in vitro cancer discrimination for in situ diagnosis.

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DOI: https://doi.org/10.1039/D6CC01461E
Article type: Communication
Submitted: 11 Mar 2026
Accepted: 11 May 2026
First published: 28 May 2026

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Chem. Commun., 2026, Advance Article

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An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition

Y. Zhou, D. Hu, X. Li, Y. Xu, P. He and H. Zhou, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC01461E

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An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition

Abstract

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An endogenous enzyme-triggered multivariate-gated DNA nanosystem for high-fidelity tumour cell recognition

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