Diasteriomeric ionic cocrystallization is introduced as a novel crystallization-based resolution tool. RS-Ibuprofen sodium is succesfully resolved using proline as a resolution agent, achieving ee>90% in a single resolution step. This work, for the first time, demonstrates diastereomeric ionic cocrystallization as a powerful approach to chiral resolution.
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T. Wen, T. Leyssens, K. Robeyns, L. Collard and F. Leng, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC01175F
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