Catalyst-Free Synthesis of α-Carboline Derivatives via Chromone Skeleton Remodeling

Abstract

A catalyst-free [3+3] annulation of indolin-2-imines with 3-formylchromones is developed to synthesize functionalized α-carboline derivatives. The chromone six-membered oxacycle undergoes ring-opening and reorganization, with its three-carbon unit embedded into the α-carboline pyridine ring.