An enantioselective Michael/O-alkylation cascade between hydroxyquinolines and chloronitroalkenes was developed, constructing chiral dihydrofuroquinoline scaffolds in high enantioselectivity under mild conditions. The direct modification of hydroxylcamptothecin and the discovery of anti-tumour (MCF-7 cell lines) leads highlight the potential of this process.
J. Wang, Y. Wei, Y. Yang, G. Bai, Y. Hua, J. Chen, H. Wang, X. Bao and D. Bonne, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00882H
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