This work presents a copper-catalyzed radical-initiated spirocyclization-oxytrifluoromethylation to synthesize spirobutyl quinolones under mild conditions with high atom economy. The products show versatile late-stage reactivity, with one serving as a dual optical sensor for Cr⁶⁺ and Ba²⁺, highlighting their practical utility.
P. Xu, Y. Xu, Y. Wang, J. L. Mao, X. Teng, Y. Y. Zhao, X. Zou, S. Yan, Z. R. Jia and H. Zuo, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00749J
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