A HClO-activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

Rui Wang; Sijie Li; Hui Wang; Yongming Yang; Mengjuan Shi; Xue Yu; Peng Lei; Xihua Yang; Shaomin Shuang; Chuan Dong; Li Fan

doi:10.1039/D6CC00671J

A HClO-activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

Rui Wang,†^a Sijie Li,†^a Hui Wang,^a Yongming Yang,^b Mengjuan Shi,^c Xue Yu,*^c Peng Lei,^a Xihua Yang,*^b Shaomin Shuang,

^a Chuan Dong

^a and Li Fan

*^a

Author affiliations

* Corresponding authors

^a Institute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P. R. China
E-mail: fanli128@sxu.edu.cn

^b Laboratory Animal Center, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, P. R. China
E-mail: yangxihua@126.com

^c School of Chemistry and Life Sciences, Changchun University of Technology, Changchun, P. R. China
E-mail: dongjibinghuayuxue@163.com

Abstract

We present an endoplasmic reticulum (ER) fluorescent probe (ER-HClO) for visualization of hypochlorous acid (HClO) in ferroptosis-mediated acute alcoholic gastric and liver injury models.

Chemical Communications

A HClO-activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

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A HClO-activated endoplasmic reticulum fluorescent probe for visualization of ferroptosis-mediated acute alcoholic gastric and liver injury

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