From the journal:

Chemical Communications

PyTTA-HOF/MXene integration with a CRISPR/Cas12 strategy for advanced homogeneous photoelectrochemical sensing

Hui-Li Yu,a   Jia-Le Wang,a   Qin-Xia Du,b   Li-Ping Jia, ORCID logo a   Wei Zhang,a   Lei Shang,a   Xiao-Jian Li,a   Huai-Sheng Wang ORCID logo *a  and  Rong-Na Ma ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P.R. China

b No. 3 Middle School of Liaocheng, Liaocheng 252059, Shandong, P.R. China
E-mail: hswang@lcu.edu.cn, marongna@lcu.edu.cn
Tel: +8686-635-8239121

Abstract

An advanced homogeneous photoelectrochemical (PEC) sensing strategy is designed based on the integration of the excellent PEC performance of PyTTA-HOF/MXene with CRISPR/Cas12a-mediated signal transduction and amplification, which can effectively avoid cumbersome, multi-step electrode modification and demonstrates satisfactory detection performance for the clinically relevant HPV-16 gene.

Graphical abstract: PyTTA-HOF/MXene integration with a CRISPR/Cas12 strategy for advanced homogeneous photoelectrochemical sensing

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Article information

DOI
https://doi.org/10.1039/D6CC00429F
Article type
Communication
Submitted
23 Jan 2026
Accepted
12 Feb 2026
First published
04 Mar 2026

Chem. Commun., 2026, Advance Article

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PyTTA-HOF/MXene integration with a CRISPR/Cas12 strategy for advanced homogeneous photoelectrochemical sensing

H. Yu, J. Wang, Q. Du, L. Jia, W. Zhang, L. Shang, X. Li, H. Wang and R. Ma, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D6CC00429F

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