Near-Infrared Fluorescence Imaging of Vimentin Dynamic Enables Evaluation of Stroke Therapy in Live Mice

Abstract

We design a novel near-infrared fluorescent probe, Vim-NIG. For the first time, Vim-NIG successfully visualized the spatiotemporal dynamics of vimentin in the brains of stroke mice. Furthermore, we demonstrated the utility of Vim-NIG for evaluating the drug efficacy. This work provides a valuable tool for advancing ischemic stroke therapeutics.

Supplementary files

Article information

Article type
Communication
Submitted
07 Jan 2026
Accepted
08 Feb 2026
First published
12 Feb 2026

Chem. Commun., 2026, Accepted Manuscript

Near-Infrared Fluorescence Imaging of Vimentin Dynamic Enables Evaluation of Stroke Therapy in Live Mice

X. Wang, S. Zhang, X. Li, Q. Ding, F. Che, W. Zhang, W. Wu and P. Li, Chem. Commun., 2026, Accepted Manuscript , DOI: 10.1039/D6CC00115G

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