Enantioselective Access to Chiral Phosphonothioates via Iridium-Catalyzed Asymmetric Allylic Substitution

Abstract

We report an efficient iridium-catalyzed asymmetric allylic substitution (AAS) protocol that enables the construction of branched allylic phosphonothioate derivatives under mild conditions. This catalytic system exhibits remarkable functional group compatibility across a structurally diverse range of substrates, delivering products with unprecedented stereocontrol (up to >99% ee) and excellent regioselectivity. By employing readily derivatizable phosphonothioic acid esters as nucleophiles, this method provides a versatile platform for accessing chiral organophosphorus scaffolds.