Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies

Xin Wang; Zhi Tong; Hongyu Liu; Hongwei Zhang; Xin Luo; Jingbin Zeng

doi:10.1039/D5CC07358H

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Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies

Xin Wang,†^a Zhi Tong,†^a Hongyu Liu,^b Hongwei Zhang,^b Xin Luo^b and Jingbin Zeng

*^a

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* Corresponding authors

^a State Key Laboratory of Chemical Safety, College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, P. R. China
E-mail: zengjb@upc.edu.cn

^b Technology Center of Qingdao Customs District, Qingdao, Shandong Province, China

Abstract

A CsPbBr₃@SiO₂–Au_shell nanoprobe enables trimodal (colorimetric/fluorescent/photothermal) lateral flow immunochromatographic assay for SARS-CoV-2 IgG detection. This multi-signal approach offers environmental adaptability and internal cross-verification, with the photothermal mode achieving the highest sensitivity (LOD: 0.4 ng mL⁻¹). The work presents a robust strategy for sensitive point-of-care testing.

This article is part of the themed collection: Chemistry for Global Health

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DOI: https://doi.org/10.1039/D5CC07358H
Article type: Communication
Submitted: 26 Dec 2025
Accepted: 10 Feb 2026
First published: 10 Feb 2026

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Chem. Commun., 2026, Advance Article

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Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies

X. Wang, Z. Tong, H. Liu, H. Zhang, X. Luo and J. Zeng, Chem. Commun., 2026, Advance Article , DOI: 10.1039/D5CC07358H

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Chemical Communications

Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies

Abstract

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Perovskite-gold shell composite nanoprobe for trimodal lateral flow immunoassay detection of SARS-CoV-2 antibodies

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