Photoinduced Three-Component Alkylpyridination of Alkenes via Spiro-Dihydroquinazolinone Fragmentation

Abstract

A visible-light-mediated three-component decyanative alkylpyridination reaction of alkenes is described. This cascade reaction is initiated by an aromatization-driven fragmentation of spiro dihydroquinazolinones, providing a streamlined approach for constructing complex 1-aryl-1-pyridylalkane scaffolds that contain a quinazolin-4(3H)-one fragment. Notably, the photocatalyst is not essential but is important for achieving good reaction efficiency. Additionally, this protocol features a broad substrate scope, good functional group compatibility, and easy scalability, highlighting its application potential in organic synthesis.