Nitrogen-rich hyper-cross-linked polymers for rapid and selective bilirubin removal in hemoperfusion

Abstract

Liver failure causes the accumulation of endogenous toxins in blood; their efficient removal is crucial to support hepatic recovery. Hemoperfusion is an effective detoxification modality but remains limited by the performance of the adsorbents. Herein, we report a benzotriazole-functionalized hyper-cross-linked polymer (HCP) with excellent performance as hemoperfusion adsorbents for removal of bilirubin. The synthesized HCP show outstanding performance for bilirubin capture, delivering a maximum adsorption capacity of 877 mg g-1 and an equilibrium capacity of 195 mg g-1. This work expands the application of HCPs and provides a viable construction strategy for development of hemoperfusion adsorbents.